Sub-lethal injection of honeybee venom decreased the levels of endogenously present substances in organs of mice
J. venom. anim. toxins
;
8(2): 255-268, 2002. graf
Artigo
em Inglês
| LILACS
| ID: lil-423230
RESUMO
Pharmacological substances such as adenosine deaminase (ADA), collagen, histamine, IgE, myoglobin, and nerve growth factor (NGF) are endogenously present in animals. Research from this laboratory reported decreased levels of ADA, histamine, IgE, and NGF in organs of mice injected with sub-lethal doses of cobra venom. The goal of this research is to observe the levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs of mice injected with venom from the bee Apis mellifera. Adult Balb/c female mice IM injected with half lethal dose of bee venom were sacrificed after 2 and 8 hours for removal of organs. The homogenates of the organs were assayed by ELISA for ADA, collagen, histamine, IgE, myoglobin, and NGF using respective antisera. Organs from mice injected with PBS were used as controls. It was observed that there were decreased levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs after 2 h and tremendous decrease after 8 h. This is the first report showing the pharmacokinetics of ADA, collagen, histamine, IgE, myoglobin, and NGF as consequence of honeybee envenomation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Venenos de Abelha
/
Imunoglobulina E
/
Histamina
/
Adenosina Desaminase
/
Colágeno
/
Fator de Crescimento Neural
/
Mioglobina
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins
Assunto da revista:
Toxicologia
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Ophidia Products Inc./US
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