Hemolitic action of Naja naja atra cardiotoxin on erythrocytes from different animals
J. venom. anim. toxins incl. trop. dis
;
12(1): 44-58, 2006. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-423833
ABSTRACT
A comparative study on the sensitivity of erythrocytes from different vertebrate species (avian, mammalian and reptilian) to the hemolytic action caused by cardiotoxin isolated from Naja naja atra venom was carried out. Cardiotoxin was able to induce direct hemolysis in washed erythrocytes from several animals, except for llama. The EC50 values from hemolysis of the most sensitive (cat) and the most resistant (snake) animal varied approximately tenfold. According to the cell behavior, it was possible to characterize four types of behavior The first was observed in cat, horse and human cells; the second in rat, rabbit and dog erythrocytes; and the third only in llama erythrocytes, which were resistant to cardiotoxin concentrations up to 300 æg/ml. Finally, avian and reptilian erythrocytes were more resistant to cardiotoxin III-induced hemolysis than those of the mammalian species.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Venenos de Serpentes
/
Proteínas Cardiotóxicas de Elapídeos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Brasil
Instituição/País de afiliação:
Fundación de Estudios Biológicos/BR
/
Universidad del Salvador/AR
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