Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
Biol. Res
;
38(2/3): 225-233, 2005. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-424726
ABSTRACT
Neuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral ventrolateral medulla are thought to provide tonic drive to the central respiratory network and involve cholinergic mechanisms, which led us to hypothesize that neuromuscular blocking agents can inhibit CO2-excited neurons and attenuate respiratory CO2 responsiveness. To test this hypothesis, we used isolated brainstem-spinal cord preparations from newborn rats. The increase of C4 burst frequency induced by a hypercapnic superfusate, i.e. respiratory CO2 responsiveness, was suppressed by the application of neuromuscular blocking agents, either d-tubocurarine (10, 100M) or vecuronium (100M). These agents (40M) also induced hyperpolarization and decreases in firing frequency of CO2-excited neurons in the rostral ventrolateral medulla. Our results demonstrate that neuromuscular blocking agents inhibit CO2-excited tonic firing neurons and attenuate respiratory CO2 responsiveness.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Respiração
/
Bloqueadores Neuromusculares
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Japão
/
Suécia
Instituição/País de afiliação:
Karolinska University Hospital and Institute/SE
/
Keio University Tsukigase Rehabilitation Center/JP
/
Keio University/JP
/
Teikyo University/JP
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