Polimorfismos dos genes da lipoproteína lipase e da apolipoproteína E: influência sobre o perfil lipídico no terceiro trimestre da gravidez / Lipoprotein lipase and apoliprotein E genetic polymorphisms: influence on lipid profile in the third trimester of pregnancy

RESUMO

O advento da genômica trouxe ferramentas capazes de identificar marcadores moleculares de suscetibilidade para dislipidemia. Nós estudamos a gravidez como fator ambiental de estresse metabólico, juntamente com o efeito de alguns polimorfismos genéticos sobre a trigliceridemia. A amostra consistiu de grávidas caucasianas aparentemente saudáveis, que foram avaliadas no terceiro trimestre.Todas as mulheres foram testadas para os polimorfismos PvuII e HindIII do gene da lipoproteína lipase e HhaI da apolipoproteína E. Os polimorfismos HindIII e HhaI influenciaram o risco para dislipidemia / The advent of genomics has brought out tools, which are capable to identify molecular markers of susceptibility to dyslipidemia. We studied pregnancy as environmental factor of metabolic stress, together with the effect of some genetic polymorphisms on triglyceridemia. The sample consisted of apparently healthy caucasian pregnant women, who were analyzed in their third trimester of pregnancy. Every woman was tested for Pvull and Hindlll polymorphisms of the lipoprotein lipase gene and Hhal of the apolipoprotein E. The polymorphisms Hindlll and Hhal have contributed to the risk of dyslipidemia...