Efecto de dosis altas de budesonida y función suprarrenal de niños asmáticos severos / High doses of inhaled budesonide and adrenal function in children with severe asthma
Rev. méd. Chile
;
134(1): 60-64, ene. 2006. tab
Artigo
em Espanhol
| LILACS
| ID: lil-426119
ABSTRACT
Background:
The use of inhaled steroids is common in the treatment of bronchial asthma in children.Aim:
To assess adrenocortical function in children with severe asthma receiving inhaled budesonide for six or more months. Material andmethods:
Children with severe asthma that required 800 µg/day or more of inhaled budesonide and that did not required systemic steroids for more than six days in the last four months to control their disease, were studied. Serum cortisol was measured one hour after administration of 0.25 mg of ACTH (Cosyntropin®) intravenously. The test was considered normal if post stimulation serum cortisol was over 18 µg/ml.Results:
Twenty children (aged 5 to 14 years, 15 males), were studied. The stimulation test was normal in 17 children.Conclusions:
Alterations in adrenal function are present in a small proportion of asthmatic children who require 800 µg/day of inhaled budesonide.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Asma
/
Broncodilatadores
/
Hidrocortisona
/
Córtex Suprarrenal
/
Budesonida
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Valparaíso/CL
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