Formulation and in vitro evaluation of theophylline-Eudragit® sustained-release tablets
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
41(3): 377-384, jul.-set.2005. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-427933
RESUMO
Tablets containing theophylline (66.67 porcento) based on a Eudragit® RS 30D and NE 30D matrices containing 10 porcento to 30 porcento of either of the polymer were produced by compression method. The influence of the different proportions of methacrylic esters, the use of lactose and tribasic calcium phosphate as diluents and also the effects of the addition of magnesium stearate as a hydrophobic agent lubricant on the theophylline release, were studied. Physicochemical analyses and drug content was evaluated. In vitro drug release studies were carried out in simulated gastric fluid without pepsin (pH1.2) and simulated intestinal fluid without pancreatin (pH7.5)...
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ácidos Polimetacrílicos
/
Teofilina
/
Técnicas In Vitro
/
Preparações Farmacêuticas
/
Desenho de Fármacos
Idioma:
Inglês
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Assunto da revista:
Bioquímica
/
Farmácia
/
Farmacologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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