Effect of the essential oil of Achillea millefolium L. in the production of hydrogen peroxide and tumor necrosis factor-"ALPHA" in murine macrophages
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
41(3): 401-405, jul.-set.2005. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-427936
RESUMO
Macrophages release more than one hundred compounds into the extracellular environment. Among these, there are cytokines and intermediate oxigen compounds, such as TNF-"ALPHA" and 'H POT. 2''O POT. 2'. We evaluated the effect of the crude essential oil of Achillea millefolium L. (Asteraceae) by determining hydrogen peroxide ('H POT. 2''O POT. 2') and tumor necrosis factor-a (TNF-"ALPHA") release in cultures of peritoneal macrophages cells from Swiss mice. Commercial azulene was also tested for comparison with the essential oil. The macrophages viability in the presence of the oil was analyzed and dilutions of 1:100 and 1:200 showed the best results. A mild production of 'H POT. 2''O POT. 2' and a moderate liberation of TNF-"ALPHA" were observed...
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Óleos Voláteis
/
Millefolium
/
Fator de Necrose Tumoral alfa
/
Macrófagos Peritoneais
/
Peróxido de Hidrogênio
Limite:
Animais
Idioma:
Inglês
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Assunto da revista:
Bioquímica
/
Farmácia
/
Farmacologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista/BR
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