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Are prostate carcinoma clinical stages T1C and T2 similar?
Billis, Athanase; Magna, Luis A; Watanabe, Isabela C; Costa, Matheus V; Telles, Gilliatt H; Ferreira, Ubirajara.
  • Billis, Athanase; State University of Campinas. School of Medicine. Department of Anatomic Pathology. Campinas. BR
  • Magna, Luis A; State University of Campinas. School of Medicine. Department of Medical Genetics and Biostatistics. Campinas. BR
  • Watanabe, Isabela C; State University of Campinas. School of Medicine. Department of Anatomic Pathology. Campinas. BR
  • Costa, Matheus V; State University of Campinas. School of Medicine. Department of Anatomic Pathology. Campinas. BR
  • Telles, Gilliatt H; State University of Campinas. School of Medicine. Department of Anatomic Pathology. Campinas. BR
  • Ferreira, Ubirajara; State University of Campinas. School of Medicine. Department of Urology. Campinas. BR
Int. braz. j. urol ; 32(2): 165-171, Mar.-Apr. 2006.
Artigo em Inglês | LILACS | ID: lil-429014
RESUMO
PURPOSE: A recent study has found that PSA recurrence rate for clinical T1c tumors is similar to T2 tumors, indicating a need for further refinement of clinical staging system. To test this finding we compared clinicopathologic characteristics and the time to PSA progression following radical retropubic prostatectomy of patients with clinical stage T1c tumors to those with stage T2, T2a or T2b tumors. MATERIALS AND METHODS: From a total of 186 consecutive patients submitted to prostatectomy, 33.52 percent had clinical stage T1c tumors, 45.45 percent stage T2a tumors and 21.02 percent stage T2b tumors. The variables studied were age, preoperative PSA, prostate weight, Gleason score, tumor extent, positive surgical margins, extraprostatic extension (pT3a), seminal vesicle invasion (pT3b), and time to PSA progression. Tumor extent was evaluated by a point-count method. RESULTS: Patients with clinical stage T1c were younger and had the lowest mean preoperative PSA. In the surgical specimen, they had higher frequency of Gleason score < 7 and more organ confined cancer. In 40.54 percent of the patients with clinical stage T2b tumors, there was extraprostatic extension (pT3a). During the study period, 54 patients (30.68 percent) developed a biochemical progression. Kaplan-Meier product-limit analysis revealed no significant difference in the time to PSA progression between men with clinical stage T1c versus clinical stage T2 (p = 0.7959), T2a (p = 0.6060) or T2b (p = 0.2941) as well as between men with clinical stage T2a versus stage T2b (p = 0.0994). CONCLUSION: Clinicopathological features are not similar considering clinical stage T1c versus clinical stages T2, T2a or T2b.
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Próstata / Neoplasias da Próstata / Antígeno Prostático Específico / Estadiamento de Neoplasias Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: State University of Campinas/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Próstata / Neoplasias da Próstata / Antígeno Prostático Específico / Estadiamento de Neoplasias Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: State University of Campinas/BR