Mitochondrial apoptotic pathways
Biocell
;
29(2): 149-161, ago. 2005. ilus
Artigo
em Inglês
| LILACS
| ID: lil-429669
RESUMO
Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution of PCD includes the release of several proapoptotic proteins from the intermembrane space of mitochondria. They could exert their actions through a caspase dependent as well as a caspase independent way. On the other hand, regulation of PCD is mainly given by the Bcl-2 family members, which are in turn essentially regulated by activation of death receptors and/or DNA damage. Nowadays, execution of apoptosis is better known than its regulation. Nevertheless, we are still far of a complete understanding of the apoptotic process
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Índice:
LILACS (Américas)
Assunto principal:
Apoptose
/
Citocromos c
/
Meato Acústico Externo
/
Homeostase
/
Mitocôndrias
Limite:
Animais
Idioma:
Inglês
Revista:
Biocell
Assunto da revista:
Clulas
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
University of Buenos Aires/AR
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