Iron and glutathione at the crossroad of redox metabolism in neurons
Biol. Res
;
39(1): 157-165, 2006. ilus
Artigo
em Inglês
| LILACS
| ID: lil-430708
RESUMO
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Estresse Oxidativo
/
Glutationa
/
Ferro
/
Degeneração Neural
/
Neurônios
Limite:
Adulto
/
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2006
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Chile/CL
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