The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells
Mem. Inst. Oswaldo Cruz
;
101(2): 207-211, Mar. 2006. ilus, graf
Artigo
em Inglês
| LILACS
| ID: lil-430898
ABSTRACT
Propolis has shown activity against pathogenic microorganisms that cause diseases in humans and animals. The ethanol (Et-Blg) and acetone (Ket-Blg) extracts from a Bulgarian propolis, with known chemical compositions, presented similar activity against tissue culture-derived amastigotes. The treatment of Trypanosoma cruzi-infected skeletal muscle cells with Et-Blg led to a decrease of infection and of the intracellular proliferation of amastigotes, while damage to the host cell was observed only at concentration 12.5 times higher than those affecting the parasite. Ultrastructural analysis of the effect of both extracts in epimastigotes revealed that the main targets were the mitochondrion and reservosomes. Et-Blg also affected the mitochondrion-kinetoplast complex in trypomastigotes, offering a potential target for chemotherapeutic agents.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Própole
/
Trypanosoma cruzi
/
Músculo Esquelético
/
Anti-Infecciosos
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fundação Oswaldo Cruz/BR
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