Assessing HIV resistance in developing countries: Brazil as a case study
Rev. panam. salud pública
;
19(3): 146-156, mar. 2006. tab
Artigo
em Inglês
| LILACS
| ID: lil-432296
RESUMO
Increased transmission of resistant HIV has been raised as a potential consequence of expanded access to antiretroviral therapy. We review how limitations in resources and health care infrastructure may impact the transmission of resistant HIV, and we examine data from Brazil as a case study. We introduce a biological and clinical framework to identify the major determinants of transmitted resistance and to discuss how these determinants may be affected by a lack of infrastructure. We then use our framework to examine HIV resistance data from Brazil. This country was chosen as a case study due to its extensive experience delivering antiretroviral drugs and because of the availability of data on the prevalence of resistant HIV there. The data from Brazil show that antiretroviral therapy can be delivered in a resource-limited setting without resulting in widespread transmission of resistant virus. While the Brazilian experience does not necessarily generalize to countries with less health care infrastructure, neither theory nor data support a foregone conclusion that resistance will necessarily dominate HIV epidemics in the developing world to a greater extent than it does in the developed world.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções por HIV
/
HIV
/
Antirretrovirais
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Rev. panam. salud pública
Assunto da revista:
Saúde Pública
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
/
Reino Unido
Instituição/País de afiliação:
Fundação Oswaldo Cruz/BR
/
Imperial College/GB
/
University of California/US
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