Biochemical and biological properties of Lonomia obliqua bristle extract
J. venom. anim. toxins incl. trop. dis
;
12(2): 156-171, 2006. tab
Artigo
em Inglês
| LILACS
| ID: lil-434717
ABSTRACT
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L. obliqua caterpillar bristle extract (LOCBE) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (DIC). Fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in LOCBE. Two procoagulant toxins, a factor X activator (Losac) and a prothrombin activator (Lopap), were isolated from LOCBE and characterized. Infusion of Lopap into experimental animals triggered a condition similar to that observed in human envenomation
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Intoxicação
/
Antivenenos
/
Coagulação Intravascular Disseminada
/
Lepidópteros
/
Mariposas
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Butantan Institute/BR
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