Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
Biol. Res
;
37(4): 539-552, 2004. graf
Artigo
em Inglês
| LILACS
| ID: lil-437507
ABSTRACT
Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cálcio
/
Músculo Esquelético
/
Canal de Liberação de Cálcio do Receptor de Rianodina
/
Cérebro
/
Miocárdio
/
Neurônios
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital Clínico de la Universidad de Chile/CL
/
Universidad de Chile/CL
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