To be or not to be
nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger?
Biol. Res
; 37(4): 559-563, 2004. ilus
Article
em En
| LILACS
| ID: lil-437509
Biblioteca responsável:
CL1.1
ABSTRACT
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems. The role of the NAADP system in physiological processes is being extensively investigated at the present time. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question. Research developed over the last two years has provided some important clues to whether NAADP is or not a physiological cellular messenger. In this short review, I will discuss some of these new findings that are helping us to find an answer to the important question Is NAADP a second messenger or not?.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Sistemas do Segundo Mensageiro
/
Cálcio
/
NADP
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biol. Res
Assunto da revista:
BIOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article