Local and global Ca2+ signals: physiology and pathophysiology
Biol. Res
;
37(4): 661-664, 2004.
Artigo
em Inglês
| LILACS
| ID: lil-437523
ABSTRACT
The pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Comunicação Celular
/
Polaridade Celular
/
Sinalização do Cálcio
Limite:
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Reino Unido
Instituição/País de afiliação:
University of Liverpool/GB
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