Early successful orchidopexy does not prevent from developing azoospermia
Int. braz. j. urol
;
32(5): 570-573, Sept.-Oct. 2006.
Artigo
em Inglês
| LILACS
| ID: lil-439391
ABSTRACT
INTRODUCTION:
The incidence of Ad spermatogonia (stem cells for fertility) was assessed in 20 cryptorchid patients, all of whom had a successful orchidopexy in childhood but developed azoospermia following puberty. MATERIALS ANDMETHODS:
From a cohort of 231 patients who had a semen analysis following successful orchidopexy 20 patients (9 percent) had azoospermia. The patients were classified into 2 groups according to the time of surgery A = < 21 months of age (n = 5, mean = 10.7 ± 8.6 months) and B = during childhood (n = 15, mean = 10.1 ± 3 years). Nine of the 20 patients (45 percent) had bilateral cryptorchidism A = 1 and B = 8. Testicular biopsies were performed during orchidopexy and analyzed with semi-thin technique. The number of Ad spermatogonia and entire number of germ cells was determined. The patients' semen analyses were evaluated at least twice; FSH and testosterone plasma values were estimated.RESULTS:
In group A, all patients had germ cells at the time of surgery (mean = 1.04 ± 1.4 germ cells per tubular cross section); only 6 patients in group B (40 percent) had no germ cells (mean = 0.17 ± 0.4); A vs. B, p = 0.0133. Importantly, Ad spermatogonia were absent in the entire study population. The plasma FSH of 16 patients (80 percent) was abnormal [median = 16.35 IU/L (Interquartile range of sample - IQR 9.075-27.85 95 percent CI, 3-53)] while the plasma testosterone of all the patients was normal.CONCLUSIONS:
The most severe cause of infertility in cryptorchid patients cannot be mitigated by an early successful surgery alone.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Espermatogônias
/
Testosterona
/
Orquiectomia
/
Criptorquidismo
/
Azoospermia
/
Hormônio Foliculoestimulante
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Suíça
Instituição/País de afiliação:
Kindertagesklinik Liestal/CH
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