Characterization of the gene expression related to the process of DNA damage tolerance in Schistosoma mansoni
Mem. Inst. Oswaldo Cruz
;
101(supl.1): 157-160, Oct. 2006. ilus
Artigo
em Inglês
| LILACS
| ID: lil-441241
ABSTRACT
In the course of its complex life cycle, the parasite Schistosoma mansoni need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents. The Schistosoma genome sequencing initiative has uncovered sequences from genes and transcripts related to the process of DNA damage tolerance as the enzymes UBC13, MMS2, and RAD6. In the present work, we evaluate the importance of this process in different stages of the life cycle of this parasite. The importance is evidenced by expression and phylogenetic profiles, which show the conservation of this pathway from protozoa to mammalians on evolution.
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Assunto principal:
Schistosoma mansoni
/
Dano ao DNA
/
DNA de Helmintos
/
Enzimas de Conjugação de Ubiquitina
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Uberlândia/BR
/
Universidade de São Paulo/BR
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