Challenges of phylogenetic analyses of aDNA sequences
Mem. Inst. Oswaldo Cruz
; 101(supl.2): 9-13, Dec. 2006. tab, ilus
Article
em En
| LILACS
| ID: lil-441337
Biblioteca responsável:
BR1.1
ABSTRACT
One of the crucial steps of authentication of aDNA sequences is phylogenetic consistency. Amplified sequences should fit into the phylogenetic framework of their supposed origin. An inherent property of aDNA sequences however, is their short sequence length. Additionally, genes for aDNA studies are often chosen by their preservation potential rather than by phylogenetically informative content. This poses potential challenges regarding their analyses, and might result in an inaccurate reflection of the supposed phylogenetic history of the sequence or organism under study. In this paper some fundamental problems of phylogenetic analysis and interpretation of aDNA datasets are discussed. Suggestions for character sampling and treatment of missing data are made. The publication is the result of a talk from the 1st PAMINSA Meeting in Rio de Janeiro, July 2005.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Filogenia
/
DNA
/
Análise de Sequência de DNA
Limite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article