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Challenges of phylogenetic analyses of aDNA sequences
Dittmar, Katharina; Souza, Sheila Mendonça de; Araújo, Adauto.
Afiliação
  • Dittmar, Katharina; Brigham Young University. Department of Integrative Biology. Provo. US
  • Souza, Sheila Mendonça de; Fiocruz. Escola Nacional de Saúde Publica Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro. BR
  • Araújo, Adauto; Fiocruz. Escola Nacional de Saúde Publica Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 101(supl.2): 9-13, Dec. 2006. tab, ilus
Article em En | LILACS | ID: lil-441337
Biblioteca responsável: BR1.1
ABSTRACT
One of the crucial steps of authentication of aDNA sequences is phylogenetic consistency. Amplified sequences should fit into the phylogenetic framework of their supposed origin. An inherent property of aDNA sequences however, is their short sequence length. Additionally, genes for aDNA studies are often chosen by their preservation potential rather than by phylogenetically informative content. This poses potential challenges regarding their analyses, and might result in an inaccurate reflection of the supposed phylogenetic history of the sequence or organism under study. In this paper some fundamental problems of phylogenetic analysis and interpretation of aDNA datasets are discussed. Suggestions for character sampling and treatment of missing data are made. The publication is the result of a talk from the 1st PAMINSA Meeting in Rio de Janeiro, July 2005.
Assuntos
Texto completo: 1 Índice: LILACS Assunto principal: Filogenia / DNA / Análise de Sequência de DNA Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2006 Tipo de documento: Article
Texto completo: 1 Índice: LILACS Assunto principal: Filogenia / DNA / Análise de Sequência de DNA Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2006 Tipo de documento: Article