Nitric oxide-oxygen radicals interactions in atherosclerosis
Biol. Res
;
33(2): 167-175, 2000. ilus
Artigo
em Inglês
| LILACS
| ID: lil-443665
ABSTRACT
Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the 'oxidative-modification hypothesis,' which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (*NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e. peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and *NO and cellular sites of production will profoundly influence the expression of differential oxidant injury-enhancing and protective effects of *NO. Full understanding of the physiological roles of *NO, coupled with detailed insight into *NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for intervention strategies directed toward oxidant-dependent atherogenic processes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Arteriosclerose
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
LDL-Colesterol
/
Óxido Nítrico
Limite:
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2000
Tipo de documento:
Artigo
País de afiliação:
Uruguai
Instituição/País de afiliação:
Universidad de la República/UY
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