Factores y mecanismos involucrados en la transmissión y el desarollo de la infección congénita por Trypanosoma cruzi / Factors and mechanisms involved in the transmission and development of congenital infection with Trypanosoma cruzi
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 105-107, 2005.
Artigo
em Espanhol
| LILACS
| ID: lil-444164
ABSTRACT
This paper synthesizes the results obtained from multidisciplinary studies of Bolivian cases of congenital infection with T. cruzi. Congenital infection and congenital Chagas disease do not result from transmission of a particular strain of parasite, but from an equilibrium between complex phenomena, such as a weak maternal type 1 adaptative immune response associated with high maternal parasitemia, an invasion of placental chorion and umbilical cord by parasites, in front of a fetal T. cruzi-specific immune response characterized by an activation of cytotoxic CD8 T cells producing IFN-gamma and able to limit parasite multiplication and morbi-mortality of congenital Chagas disease.
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Índice:
LILACS (Américas)
Assunto principal:
Trypanosoma cruzi
/
Doença de Chagas
/
Complicações Parasitárias na Gravidez
/
Transmissão Vertical de Doenças Infecciosas
Limite:
Animais
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Espanhol
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2005
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Bélgica
Instituição/País de afiliação:
Université Livre de Bruxelles/BE
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