Transcriptome overview of Paracoccidioides brasiliensis proteases
Genet. mol. res. (Online)
;
4(2): 358-371, 30 jun. 2005. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-445282
ABSTRACT
Proteases perform a wide variety of functions inside and outside cells, regulating many biological processes. Infectious microorganisms use proteases, either secreted or attached to their cell surface to weaken and invade their hosts. Therefore, proteases are targets for drugs against a diverse set of diseases. Paracoccidioides brasiliensis is the most prevalent fungal pathogen causing systemic mycosis in Latin America. The development of paracoccidioidomycosis depends on interactions between fungal and host components and proteases have been described as important factors implicated in the mechanism of host colonization by fungi. The primary goal for this study is to present an overview of the transcriptome sequences--identified cDNAs that encode proteases. We obtained a total of 53 cDNAs encoding proteases; 15 were classified as ATP-independent, 12 as ATP-dependent, 22 as proteasome subunits, and 4 as deubiquitinating proteases. The mechanisms and biological activity of these proteases differ in substrate specificity and in catalytic mechanisms.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Paracoccidioides
/
Peptídeo Hidrolases
/
Transcrição Gênica
/
Regulação Fúngica da Expressão Gênica
/
DNA Complementar
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Genet. mol. res. (Online)
Assunto da revista:
Biologia Molecular
/
Genética
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Goiás/BR
Similares
MEDLINE
...
LILACS
LIS