A novel nonsense mutation, E150X, in the SOX9 gene underlying campomelic dysplasia
Genet. mol. biol
;
29(4): 617-620, 2006. ilus, graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-450481
ABSTRACT
Campomelic dysplasia (CD) is an autosomal dominant skeletal malformation syndrome with features including bowed lower limbs with pretibial skin dimpling, hypoplastic scapulae and pelvic bones, and 11 pairs of ribs. Mutations in the SOX9 gene have been identified to cause CD. The gene encodes a transcription factor containing a dimerization, a high mobility group, and a C-terminal transactivation (TA) domain. Up to now, 35 SOX9 mutations have been published. In the present study, we describe a Thai girl with clinically and radiologically typical CD. Direct sequencing analysis of the PCR products for the entire coding region of SOX9 revealed that she was heterozygous for a novel 448G > T in exon 2 of SOX9. The DNA change was expected to result in E150X and loss of the entire TA domain. This result further supports that SOX9 is the only gene, discovered to date, responsible for CD across different populations and that the TA domain is important to the function of the normal SOX9.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fatores de Transcrição
/
Doenças do Desenvolvimento Ósseo
/
Mutação
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Lactente
/
Masculino
/
Recém-Nascido
/
Gravidez
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Tailândia
Instituição/País de afiliação:
Chulalongkorn University/TH
/
Prince of Songkla University/TH
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