Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Mem. Inst. Oswaldo Cruz
;
102(3): 417-420, June 2007. tab
Artigo
em Inglês
| LILACS
| ID: lil-452507
ABSTRACT
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Proteínas de Membrana Transportadoras
/
Proteínas de Protozoários
/
Cloroquina
/
Clorfeniramina
/
Malária Falciparum
/
Amodiaquina
/
Antagonistas dos Receptores Histamínicos H1
/
Antimaláricos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Nigéria
Instituição/País de afiliação:
University of Ibadan/NG
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