Avascular necrosis of the femoral head in HIV infected patients
Braz. j. infect. dis
;
11(1): 31-34, Feb. 2007. tab
Artigo
em Inglês
| LILACS
| ID: lil-454706
ABSTRACT
Avascular necrosis (AVN) of the femoral head is an emerging complication in HIV infected patients. It has been suggested that the increased incidence of AVN in this population may be caused by an increased prevalence of predisposing factors for osteonecrosis, including protease inhibitors, hyperlipidemia, corticosteroid use, alcohol and intravenous drug abuse. The aim of this study was to assess the risk factors for avascular necrosis developing in the femoral head of HIV infected individuals. This study consisted of meta-analysis of the secondary data extracted from current literature. The selected articles allowed two study groups to be drawn up for comparison. Group 1 comprised 324 individuals infected by the HIV virus, who did not present femoral head AVN. Group 2 comprised 32 HIV positive patients, who presented femoral head AVN. The parameters used for analysis were as follows age, gender, sexual preference, use of intravenous drugs, time of diagnosis, CD4+ cell count, use of antiretroviral agents and duration, serum cholesterol and serum triglycerides. The present study found a statistically significant association between hypertriglyceridemia, hypercholesterolemia, sexual preference and intravenous drug abuse. The authors concluded that femoral head osteonecrosis is associated with hyperlipidemia (hypercholesterolemia and hypertriglyceridemia) and intravenous drug abuse. This study supports the hypothesis that protease inhibitors play a role in the development of osteonecrosis through a tendency to cause hyperlipidemia.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hipertrigliceridemia
/
Infecções por HIV
/
Inibidores da Protease de HIV
/
Fármacos Anti-HIV
/
Necrose da Cabeça do Fêmur
/
Hipercolesterolemia
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Medical School of Medicine and Public Health/BR
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