Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs
Biol. Res
;
40(1): 55-63, 2007. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-456608
ABSTRACT
Oxytocin is extensively used to induce or augment uterine contractions, especially to facilitate the third stage of labor in humans. Administration of oxytocin to parturient sows reduces duration of labor whereas mortality of the offspring may remain unchanged. This study aimed to evaluate whether time of administration of oxytocin during parturition may alter the uterine response and fetal outcomes. Two hundred parturient sows were randomly assigned to intramuscularly receive either saline solution (control group) or oxytocin 0.083 IU/kg immediately after the delivery of the 1st, 4th or 8th piglet (groups O-1, 0-4 and 0-8, respectively). Uterine effects and fetal outcomes were registered in all groups. The duration of labor was 20-40 min shorter (P < 0.0001) and time interval between babies was reduced by 3-5 min (P < 0.0001) in the three groups receiving oxytocin. The duration and intensity of contractions, meconium-stained piglets and intrapartum deaths decreased as time at which oxytocin administered during labor was increased. In group 0-8, we observed approximately 70 percent less meconium-stained piglets and intrapartum deaths than in the control group. In conclusion, oxytocin administered at early phases of parturition to sows may increase duration and intensity of uterine contractions as well as adverse fetal outcomes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ocitócicos
/
Contração Uterina
/
Ocitocina
/
Parto
/
Natimorto
/
Miométrio
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2007
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Canadá
/
México
Instituição/País de afiliação:
Hospital Infantil de México Federico Gómez/MX
/
Hospital for Sick Children/CA
/
Universidad Autónoma Metropolitana-Xochimilco/MX
/
Universidad Nacional Autónoma de México/MX
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