Prevalence of HBV genotypes in South American immigrants affected by HBV-related chronic active hepatitis
Braz. j. infect. dis
;
11(3): 311-313, June 2007. tab
Artigo
em Inglês
| LILACS
| ID: lil-457628
ABSTRACT
This study evaluated the prevalence of HBV infection in a population of South American immigrants in Italy and to determine in patients with detectable serum HBV-DNA the HBVgenotypes. Between April 2005 and April 2006 a total of 130 South American immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV genotype was determined by INNOLiPA. Among the 130 subjects tested, 14 (10.7 percent) resulted HBsAg positive. All were men, with a mean age of 22 years (range 19-37) and 12 (85.7 percent) came from Brazil, while 2 (14.3 percent) came from Ecuador. All patients infected by HBV had elevated alanine-aminotransferase serum levels (mean level was 127 IU/L, range 74-312) and serum HBV DNA detectable by PCR-Real Time (mean level 1,037,652 copies/mL, range 19,876-1,377,648). Genotype distribution was as follow genotype D, 9 (64.2 percent), genotype A, 5 (35.8 percent). All patients infected by genotype D came from Brazil, while among the patients infected by genotype A, three came from Brazil and two from Ecuador. Our study evidences a moderate prevalence of HBV-infection in South American immigrants with the identification of two genotypes, D and A. These genotypes are not the most prevalent in the South America and this is probably the expression of a possible geographical redistribution of HBV genotypes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vírus da Hepatite B
/
Hepatite B Crônica
Tipo de estudo:
Estudo diagnóstico
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Europa
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Itália
Instituição/País de afiliação:
University of Foggia/IT
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