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Polymorphism in 1908STR1934 locus of the 3. UTR of the Nramp1 bovine gene in eight cattle breeds
Gonzáles S., Jenny P; Saldarriaga, Omar A; López Herrera, Albeiro; Bermúdez, Nelson R; Zapata B., Wildeman; Ossa, Jorge E; Rugeles L., María T; Bedoya B., Gabriel.
  • Gonzáles S., Jenny P; Universidad de Antioquia. Grupo Inmunovirología-Biogénesis. Medellín. CO
  • Saldarriaga, Omar A; Universidad de Antioquia. Grupo Inmunovirología-Biogénesis. Medellín. CO
  • López Herrera, Albeiro; Universidad Nacional de Colombia. Facultad de Ciencias Agropecuarias. Departamento de Producción Animal. Grupo Biogem. Medellín. CO
  • Bermúdez, Nelson R; Universidad de Antioquia. Laboratorio Genética Molecular. Medellín. CO
  • Zapata B., Wildeman; Universidad de Antioquia. Grupo Inmunovirología-Biogénesis. Medellín. CO
  • Ossa, Jorge E; Universidad de Antioquia. Medellín. CO
  • Rugeles L., María T; Universidad de Antioquia. Grupo Inmunovirología-Biogénesis. Medellín. CO
  • Bedoya B., Gabriel; Universidad de Antioquia. Laboratorio Genética Molecular. Medellín. CO
Rev. colomb. cienc. pecu ; 19(1): 11-17, mar. 2006. tab, graf
Artigo em Inglês | LILACS | ID: lil-462999
RESUMEN
The Nramp1 gene has been associated with natural resistance to intracellular microorganisms in several species including bovine. Recent evidence suggests an association between polymorphism in the 3. untranslated region (3. UTR) of this gene with resistance/susceptibility (R/S) to Brucella abortus as determined in vivo and in vitro. In this study we tested for the variability of the short tandem repeat (STR) within the 3. UTR of Nramp1 in six breeds of Colombian creole cattle (CCC) and compared the genotypes with those of Holstein and Brahman, which were recently introduced into this country. In CCC as well as in Holstein we found the allele 175 fixed in all populations. In Brahman, 175 allele was also present with a frequency of 0.467 but additionally, in this breed there appeared five other alleles and among them two previously unreported 183 y 185; also was found the allele 189 in the Colombian creole Harton del Valle cattle, which is not previously reported. Together these results suggest that the 175 allele in the 3. UTR Nramp1 may be an ancestral allele in cattle and if this is true the association previously reported with the R/S trait requires further evaluation.
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Polimorfismo Genético / Bovinos / Inseminação Limite: Animais Idioma: Inglês Revista: Rev. colomb. cienc. pecu Assunto da revista: Medicina Veterinária Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Colômbia Instituição/País de afiliação: Universidad Nacional de Colombia/CO / Universidad de Antioquia/CO

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Polimorfismo Genético / Bovinos / Inseminação Limite: Animais Idioma: Inglês Revista: Rev. colomb. cienc. pecu Assunto da revista: Medicina Veterinária Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Colômbia Instituição/País de afiliação: Universidad Nacional de Colombia/CO / Universidad de Antioquia/CO