Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
Biol. Res
;
40(2): 155-162, 2007. graf
Artigo
em Inglês
| LILACS
| ID: lil-468186
ABSTRACT
The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cobre
/
Ácidos Aminossalicílicos
/
Lipoproteínas LDL
/
Antioxidantes
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2007
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
/
Universidad de Santiago de Chile/CL
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