Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis
Int. braz. j. urol
;
33(5): 603-621, Sept.-Oct. 2007. ilus
Artigo
em Inglês
| LILACS
| ID: lil-470211
ABSTRACT
Oxidative stress (OS) in the reproductive tract is now a real entity and concern due to the potential harmful effects of high levels of reactive oxygen species (ROS) on sperm number, motility, quality, and function including damage to sperm nuclear DNA. Evaluation of OS related damage to non-functional sperm is highly relevant as intracytoplasmic sperm injection (ICSI) technique, an effective therapy for severe male factor infertility, bypasses the majority of reproductive tract deficiencies. Despite the controversial findings in the existing literature, there is now enough evidence to show that sperm DNA damage is detrimental to reproductive outcomes. In addition, spermatozoa of infertile men are suggested to carry more DNA damage than do the spermatozoa from fertile men. Besides impairment of fertility such damage is likely to increase the transmission of genetic diseases during the assisted reproductive procedures. Standardization of protocols to assess reactive oxygen species and DNA damage is very important in introducing these tests in such clinical practice. Thus evaluation of seminal ROS levels and extent of sperm DNA damage especially in an infertile male may help develop new therapeutic strategies and improve success of assisted reproductive techniques (ART).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Espermatozoides
/
Dano ao DNA
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Infertilidade Masculina
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Cleveland Clinic/US
/
Tulane University Health Sciences Center/US
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