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Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma
Piccoli, Michelly F; Figueira, Marcia; Andreoni, Cassio; Marumo, Julio T; Schor, Nestor; Bellini, Maria H.
  • Piccoli, Michelly F; Federal University of Sao Paulo. Section of Nephrology and Section of Urology. Sao Paulo. BR
  • Figueira, Marcia; Federal University of Sao Paulo. Section of Nephrology and Section of Urology. Sao Paulo. BR
  • Andreoni, Cassio; Federal University of Sao Paulo. Section of Urology. Sao Paulo. BR
  • Marumo, Julio T; Institute of Energetic and Nuclear Research. Sao Paulo. BR
  • Schor, Nestor; Federal University of Sao Paulo. Section of Nephrology and Section of Urology. Sao Paulo. BR
  • Bellini, Maria H; Institute of Energetic and Nuclear Research. Sao Paulo. BR
Int. braz. j. urol ; 33(5): 622-629, Sept.-Oct. 2007. ilus, tab
Artigo em Inglês | LILACS | ID: lil-470212
ABSTRACT

OBJECTIVE:

Investigate the possible association of insertion/deletion (2G/G) polymorphism at nucleotide -1607 of the MMP-1 promoter with the development and progression of renal cancer MATERIALS AND

METHODS:

In this study, we genotyped 217 individuals, 99 patients with renal cell carcinoma (RCC) and 118 controls without cancer. DNA specimens were extracted from epithelial buccal cells and paraffin-embedded tissue of RCC patients and from epithelial buccal cells and blood cells of healthy controls

RESULTS:

The difference in frequency of 2G/2G genotype between controls (22.9 percent) and RCC patients (28.6 percent) was not statistically significant (p = 0.461). We also did not find correlation between 2G/2G and histological type of RCC. The comparison of genotype distribution and frequency of 2G allele in different populations showed a strong variability of 2G allele frequency among the different ethnic groups. This fact may influence on the collaboration of this 2G allele in RCC or others diseases

CONCLUSION:

Our data suggest that the matrix metalloproteinase-1 (MMP-1) promoter polymorphism may not play a significant role in renal cell carcinoma patients in Brazil.
Assuntos

Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Carcinoma de Células Renais / Regiões Promotoras Genéticas / Metaloproteinase 1 da Matriz / Polimorfismo de Nucleotídeo Único / Neoplasias Renais Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Sao Paulo/BR / Institute of Energetic and Nuclear Research/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Carcinoma de Células Renais / Regiões Promotoras Genéticas / Metaloproteinase 1 da Matriz / Polimorfismo de Nucleotídeo Único / Neoplasias Renais Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Sao Paulo/BR / Institute of Energetic and Nuclear Research/BR