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Alfa 1 antitrypsin and protease levels in Puerto Rican asthmatics: a pilot study
Montealegre, F; Delgado, A; Toro, A; Vargas, W; Chardon, D; Bayona, M; Campbell, E.
  • Montealegre, F; Ponce School of Medicine. Department of Microbiology. Ponce. PR
  • Delgado, A; s.af
  • Toro, A; s.af
  • Vargas, W; s.af
  • Chardon, D; s.af
  • Bayona, M; s.af
  • Campbell, E; s.af
P. R. health sci. j ; 25(2): 117-125, Jun. 2006.
Artigo em Inglês | LILACS | ID: lil-472192
ABSTRACT
A cross-sectional pilot study was conducted on a population of 119 asthmatics who had been recruited from the Emergency Room Department of a major hospital in Ponce, Puerto Rico. The purpose of the study was to determine the frequency of the MM, MS, and SS a-i-antiprotease variants. Also, we analyzed the serum levels of the alpha-1-antiprotease inhibitor, quantified the levels of serine proteases in homes of the asthmatic volunteers, and determined whether environmental levels of proteases, regardless of their sources, had any association with either asthma symptoms or alpha-1-antiprotease inhibitor phenotypes. Our results do not support the role of the alpha-1-antiprotease as a risk factor for asthma in the study population as previously reported. Patients who had visited the ED due to asthma on 3 or more occasions had significantly higher trypsin levels than those who had done so 2 or fewer times. Of those asthmatic patients who had daily symptoms, 40had been exposed to high levels of elastase, and 33.3to trypsin. Similarly, 52.9of the patients with 2 or more hospitalizations a year had been exposed to high elastase levels, and 40.5of asthma patients who had nocturnal asthma more than 3 times a week had been exposed to high levels of elastase.
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Índice: LILACS (Américas) Assunto principal: Peptídeo Hidrolases / Asma / Alfa 1-Antitripsina Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Adulto / Humanos País/Região como assunto: Caribe / Porto Rico Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Porto Rico Instituição/País de afiliação: Ponce School of Medicine/PR

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Índice: LILACS (Américas) Assunto principal: Peptídeo Hidrolases / Asma / Alfa 1-Antitripsina Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Adulto / Humanos País/Região como assunto: Caribe / Porto Rico Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Porto Rico Instituição/País de afiliação: Ponce School of Medicine/PR