Antifungal properties of plants used in Brazilian traditional medicine against clinically relevant fungal pathogens

ABSTRACT

Antifungal properties of extracts from eight Brazilian plants traditionally used in popular Brazilian medicine were tested against five clinically relevant Candida species, Cryptococcus neoformans, and Sporothrix schenckii. Results demonstrate that almost all extracts exhibited antifungal activity, at least against one of the microorganisms tested. The ethanolic extract from the leaves of Schinus terebinthifolius exhibited potential antifungal activity against C. glabrata and S. schenckii. Preliminary phytochemical analysis of extract from S. terebinthifolius showed the presence of biologically active compounds, namely saponins, flavonoids, triterpenes, steroids and tannins.

RESUMO

A propriedade antifúngica de extratos de oito plantas utilizadas na medicina tradicional brasileira foi testada contra cinco espécies de Candida, com relevância clínica, Cryptococcus neoformans e Sporothrix schenckii. Os resultados mostraram que todos os extratos exibiram atividade antifúngica contra pelo menos um dos microrganismos testados. O extrato etanólico das folhas de Schinus terebinthifolius apresentou potencial atividade antifúngica contra C. glabrata e S. schenckii. Na análise fitoquímica preliminar dos extratos de S. terebinthifolius observou-se a presença de compostos biologicamente ativos como, flavonóides, triterpenos, esteróides e taninos.