Papel de la Toxina Shiga en el sindrome urémico hemolítico / Role of the Shiga toxin in the hemolytic uremic syndrome
Medicina (B.Aires)
;
66(supl.2): 11-15, 2006.
Artigo
em Espanhol
| LILACS
| ID: lil-480132
ABSTRACT
In the last years, infection associated with Shiga toxin-producing Escherichia coli (STEC) and subsequent Hemolitic-Uremic Syndrome (HUS) became relevant as a public health since it was considered as one of the most important emergent patogen present in the food contaminated by cattle feces. STEC infection may be asymptomatic or begins with a watery diarrhea that may or may not progress to bloody diarrhea (hemorrhagic colitis) and HUS. In Argentina, HUS is the most common pediatric cause of acute renal insufficiency and the second cause of chronic renal failure. Up to now, STEC infection lacks of known effective treatment strategies that diminish risk of progression to HUS. The mechanisms by which Shiga toxin (Stx) induce HUS may help to find strategies to prevent or ameliorate HUS. In this article, recent progress that has contributed to understanding the disease pathogenesis of STEC is reviewed. New strategies to prevent further uptake of Shiga from the gut, either during the diarrheal phase or once HUS has developed are discussed.
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Índice:
LILACS (Américas)
Assunto principal:
Toxinas Shiga
/
Infecções por Escherichia coli
Limite:
Humanos
Idioma:
Espanhol
Revista:
Medicina (B.Aires)
Assunto da revista:
Medicina
Ano de publicação:
2006
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad de Buenos Aires/AR
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