Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications
Braz. j. med. biol. res
;
41(5): 344-350, May 2008. ilus
Artigo
em Inglês
| LILACS
| ID: lil-484442
ABSTRACT
T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-ß, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the correct stratification of patients into appropriate therapeutic regimens and to identify novel targets for the development of specific, less detrimental therapies for T-ALL.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fosfotransferases
/
Linfócitos T
/
Leucemia-Linfoma de Células T do Adulto
/
Transdução de Sinais
/
Diferenciação Celular
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2008
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Portugal
Instituição/País de afiliação:
Universidade de Lisboa/PT
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