Effects of prenatal stress on male offspring sexual maturity
Biocell
;
31(1): 67-74, abr. 2007. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-491531
ABSTRACT
Prenatal stimulations have been shown to have long-term effects on at reproductive activity. We evaluated the influence of the prenatal stress on the hypothalamic-pituitary-gonad (HPG) axis in male offsprings from mothers with high number of offsprings per litter (HNL) and low number of offsprings per litter (LNL) after hypothesizing that the number of offsprings per litter may modify the effect of the prenatal stress on the HPG of adult offsprings. Pregnant Wistar rats were used for this study. Immobilization (IMO) stress was used, 30 min, 3 times per week, from the 5th to 21st day of pregnancy. The weight of adrenal and gonads, and the corticosterone (COR), testosterone (TES) and luteinizing hormone (LH) plasmatic levels were analyzed in the male offspring at 30, 45 and 70 days of age. The offspring males coming from LNL showed a decrease in testicle weight and TES levels, without changes in the plasmatic LH levels. However, the offspring of HNL showed a decrease of LH levels. It is possible to conclude that in LNL prenatal stress would produce alterations to gonadal level, while in HNL the effect of stress would be evident at pituitary level.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hipófise
/
Maturidade Sexual
/
Estresse Fisiológico
/
Testículo
/
Corticosterona
/
Hormônio Luteinizante
/
Hipotálamo
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Biocell
Assunto da revista:
Clulas
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
Universidad Nacional de Río Cuarto/AR
Similares
MEDLINE
...
LILACS
LIS