Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains
Mem. Inst. Oswaldo Cruz
;
103(6): 606-610, Sept. 2008. graf, tab, ilus
Artigo
em Inglês
| LILACS, SES-SP
| ID: lil-495738
ABSTRACT
In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Salmonella typhimurium
/
Vacinas contra Salmonella
/
Flagelina
/
Anticorpos Antibacterianos
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Butantan/BR
/
Universidade de São Paulo/BR
/
University of Oklahoma/US
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