Free radical scavenging profile and myeloperoxidase inhibition of extracts from antidiabetic plants: Bauhinia forficata and Cissus sicyoides
Biol. Res
;
41(2): 165-171, 2008. graf
Artigo
em Inglês
| LILACS
| ID: lil-495751
ABSTRACT
There is abundant evidence that reactive oxygen species are implicated in several physiological and pathological processes. To protect biological targets from oxidative damage, antioxidants must react with radicáis and other reactive species faster than biological substrates do. The aim of the present study was to determine the in vitro antioxidant activity of aqueous extracts from leaves of Bauhinia forficata Link (Fabaceae - Caesalpinioideae) and Cissus sicyoides L. (Vitaceae) (two medicinal plants used popularly in the control of diabetes mellitus), using several different assay systems, namely, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) decolorization, superoxide anión radical (0(2)-) scavenging and myeloperoxidase (MPO) activity. In the ABTS assay for total antioxidant activity, B. forficata showed IC50 = 8.00±0.07 μg/mL, while C. sicyoides showed IC50 = 13.0±0.2 μg/mL. However, the extract of C. sicyoides had a stronger effect on 0(2)- (IC50 = 60.0±2.3 μg/mL) than the extract of B. forficata (IC50 = 90.0±4.4 μg/ mL). B. forficata also had a stronger inhibitory effect on MPO activity, as measured by guaiacol oxidation, than C. sicyoides. These results indicate that aqueous extracts of leaves of B. forficata and C. sicyoides are a potential source of natural antioxidants and may be helpful in the prevention of diabetic complications associated with oxidative stress.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Extratos Vegetais
/
Sequestradores de Radicais Livres
/
Peroxidase
/
Bauhinia
/
Cissus
/
Hipoglicemiantes
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Sao Paulo State University/BR
Similares
MEDLINE
...
LILACS
LIS