Producción de prostaciclina en arteria radial de diabéticos: comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios / Prostacyclin production in internal mammary ano radial arteries and saphenous veins of diabetic and non diabetic subjects
Rev. méd. Chile
;
136(7): 823-830, jul. 2008. graf, tab
Artigo
em Espanhol
| LILACS
| ID: lil-496001
ABSTRACT
Background:
Myocardial revascularization surgery has used several vessels as coronary grafts including internal mammary and radial arteries which have a better prognosis than saphenous vein. Their long-term patency has been associated with the reléase of endothelium vasodilator and anti-aggregating producís such as prostacyclin. Diabetes induces endothelial dysfunction and a high number of diabetics require revascularization.Aim:
To assess the capacity to synthesize prostacyclin of different vessels from diabetics. Material andmethods:
Internal mammary and radial arteries and saphenous veins obtained from 10 diabetic and 10 non diabetic patients subjected to coronary artery bypass surgery were studied. The capacity to synthesize prostacyclin was assessed in these vessels measuríng its hydrolysis product, the 6-keto-PGFla by radioimmunoassay.Results:
Internal mammary arteries and saphenous veins from diabetics synthesized a lower amount of prostacyclin than those from non-diabetics. The radial artery produced similar amounts of prostacyclin in both groups. This response was associated with an increase of the conversión of the precursor arachidonic acid to prostacyclin. The saturating concentrations of this acid required to achieve the maximal stimulation were higher in the radial artery (20 µM) than in the internal mammary artery and saphenous vein (10 µM), suggesting that the enzymatic activity of the radial artery was not affected by diabetes.Conclusions:
The radial artery appears as the best replacement vessel for coronary surgery in diabetics. Its favorable biochemical profile and potential lower long-term occlusion rate may be relevant for a better prognosis of myocardial revascularization in these patients.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Veia Safena
/
Ponte de Artéria Coronária
/
Epoprostenol
/
Artéria Radial
/
Complicações do Diabetes
/
Artéria Torácica Interna
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital DIPRECA/CL
/
Universidad de Chile/CL
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