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Survival prognostic factors in esophagectomized patients due to squamous cell carcinoma of the esophagus
Coimbra, Felipe Jose Fernandez; Sallum, Rubens Antonio Aissar; Montagnini, Andre Luis; Nishimoto, Ines Nobuko.
  • Coimbra, Felipe Jose Fernandez; Fundação Antônio Prudente. Hospital A C Camargo. Departamento de Cirurgia Abdomial. São Paulo. BR
  • Sallum, Rubens Antonio Aissar; Fundação Antônio Prudente. Hospital A C Camargo. Departamento de Cirurgia Abdomial. São Paulo. BR
  • Montagnini, Andre Luis; Fundação Antônio Prudente. Hospital A C Camargo. Departamento de Cirurgia Abdomial. São Paulo. BR
  • Nishimoto, Ines Nobuko; Fundação Antônio Prudente. Hospital A C Camargo. Departamento de Cirurgia de Cabeça e Pescoço-Serviço de Estatística. São Paulo. BR
Appl. cancer res ; 27(4): 175-181, 2007.
Artigo em Inglês | LILACS, Inca | ID: lil-497101
ABSTRACT
Introduction: Among esophageal tumors, squamous cell carcinoma is the most common and with a poor outcome. Itsprognostic factors are controversial and the long-term results dismal. It is essential, though, to have a detailed knowledge of the characteristics of this group of patients and its prognostic factors. Objective: To evaluate clinical, surgical and pathologicalparameters of patients with esophageal squamous cell carcinoma submitted to esophagectomy and identify prognostic factors of overall survival. Secondary Objectives: To evaluate surgery safety and mortality. Methods: A retrospective cohort study was done with 47 patients submitted to esophagectomy due to squamous cell esophageal cancer admitted in the Abdominal Surgery Department of A.C.Camargo Cancer Hospital, Sao Paulo. The period considered was October 1998 - December 2004. Results: Overall 2 and 5-year survival rates were 41.1% and 18.1%, respectively. There were statistically significant differences in 5-year overall survival probability for the treatment intention (p=0.0017), residual disease (R) (p=0.0111),lymphatic invasion (p=0.0180), T (p=0.0077), M (p=0.0166), clinical stage (p=0.0020). The independent prognostic factors were lymphatic invasion (HR=2.41) and pathologic “T“ (HR=2.19). Conclusions: Surgical treatment of esophageal cancer is a safe procedure, with low hospital mortality (2.1 %). The most important factors associated to 5-year overall survivalis treatment intention, residual disease (R), lymphatic invasion, and T M clinical stage. Independent prognostic factors are lymphatic invasion and pathologic T.
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Prognóstico / Neoplasias Esofágicas / Carcinoma / Carcinoma de Células Escamosas / Esofagectomia / Esôfago / Neoplasias Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Fundação Antônio Prudente/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Prognóstico / Neoplasias Esofágicas / Carcinoma / Carcinoma de Células Escamosas / Esofagectomia / Esôfago / Neoplasias Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Fundação Antônio Prudente/BR