Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
Mem. Inst. Oswaldo Cruz
;
103(8): 754-759, Dec. 2008. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-502293
ABSTRACT
Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction. Over half of recrudescent events occurred after 14 days of initiation of treatment and were associated with relatively low asexual parasitaemia. We examined the gametocyte sex ratio (GSR) in these children and in age and gender-matched controls that had AQ-sensitive (AQ-S) infections (n = 50). In both AQ-S and AQ-resistant (AQ-R) infections, the GSR was female-biased pre-treatment and became male-biased by the third day after treatment initiation. However, gametocyte males persisted after this period in children with AQ-R infections. AQ-recrudescent infections are relatively low (25 of 612.4 percent) in children from this endemic area.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plasmodium falciparum
/
Malária Falciparum
/
Amodiaquina
/
Antimaláricos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Nigéria
Instituição/País de afiliação:
University of Ibadan/NG
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