Group A rotavirus genotypes and the ongoing Brazilian experience: a review
Mem. Inst. Oswaldo Cruz
;
103(8): 745-753, Dec. 2008. graf
Artigo
em Inglês
| LILACS
| ID: lil-502309
ABSTRACT
Brazil was the first Latin American country to introduce universal group A rotavirus (RV-A) vaccination in March 2006, resulting in a unique epidemiological scenario. Since RV-A first identification in Brazil, 2,691 RV-A-positive stool samples, collected between 1982- 2007, were typed by independent research groups throughout the country. In the pre-vaccination era, 2,492 RV-A-positive samples collected from 1982-2005 were successfully typed, while 199 samples were analyzed from 2006-2007. According to the reviewed studies, there were two important times in the pre-vaccination era (i) the period from 1982-1995, during which the detection of G5P[8] RV-A, in addition to the classical genotypes G1-4, challenged vaccine development programs; and (ii) the period from 1996-2005, during which genotype G9P[8] emerged, following a global trend. The rate of G2P[4] RV-A detection decreased from 26 percent (173/653) during 1982-1995 to 2 percent (43/1,839) during 1996-2005. The overall detection rate of RV-A genotypes from 1982-2005 was as follows 43 percent (n = 1,079) G1P[8]/G1P[not typed (NT)]; 20 percent (n = 488) G9P[8]/G9P[NT]; 9 percent (n = 216) G2P[4]/G2P[NT]; 6 percent (n = 151) G3P[8]/G3P[NT]; 4 percent (n = 103) G4P[8]/G4P[NT]; and 4 percent (n = 94) G5P[8]/G5P[NT]. Mixed infections accounted for 189 (7 percent) of the positive samples, while atypical G/P combinations or other genotypes, including G6, G8, G10 and G12, were identified in 172 (7 percent) samples. The initial surveillance studies carried out in several Brazilian states with RV-A-positive samples collected in 2006 and 2007 show a predominance of G2P[4] strains (148/199 or 74 percent). Herein, we review RV-A typing studies carried out since the 1980s in Brazil, highlighting the dynamics of RV-A strain circulation profiles before and early after universal use of RV-A vaccine in Brazil.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções por Rotavirus
/
Rotavirus
/
Vacinas contra Rotavirus
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fiocruz/BR
/
Secretaria de Vigilância em Saúde/BR
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