Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit
Braz. j. infect. dis
;
12(5): 395-399, Oct. 2008. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-505353
ABSTRACT
We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Candida
/
Candidíase
/
Infecção Hospitalar
/
Surtos de Doenças
/
Fungemia
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Japão
/
Turquia
Instituição/País de afiliação:
Gazi University/TR
/
Meiji Pharmaceutical University/JP
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