Reduction of postsurgical adhesions in a rat model: a comparative study
Clinics
;
64(2): 143-148, 2009. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-505376
ABSTRACT
BACKGROUND:
Adhesion formation after peritoneal surgery is a major cause of postoperative bowel obstruction, infertility, and chronic pelvic pain. In this study, we compared the possible individual effects of phosphatidylcholine (PC), Seprafilm® II, and tissue plasminogen activator (t-PA) and the combined effects of phosphatidylcholine and t-PA on postoperative adhesion formation in a rat surgical model. MATERIALS ANDMETHODS:
A total of 50 Wistar male rats underwent median laparotomy and standardized abrasion of the visceral and parietal peritoneum. phosphatidylcholine, Seprafilm II, and t-PA alone and phosphatidylcholine and t-PA in combination were applied intraperitoneally at the end of the surgical procedure. Seven days after surgery, a relaparotomy was performed for adhesion grading and histopathological examination.RESULTS:
A comparison of adhesion stages demonstrated a significant difference between the control group and the study groups (p<0.001). The adhesion grade of the combined treatment group was statistically different from that of the other groups (p<0.05). In the t-PA group and the combined group, six and two rats, respectively, developed hematomas locally on the cecum.CONCLUSIONS:
PC, t-PA, and Seprafilm II used individually reduced the adhesion grade. The t-PA and phosphatidylcholine combination was most effective in reducing adhesion formation. On the other hand, usage of t-PA alone or in combination may increase risk of bleeding. More detailed studies are needed, and future studies on the efficacy of a material for decreasing adhesion formation should include a comparison of several control materials in the same model.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças Peritoneais
/
Fosfatidilcolinas
/
Complicações Pós-Operatórias
/
Ativador de Plasminogênio Tecidual
/
Fibrinolíticos
/
Ácido Hialurônico
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Gazi University/TR
/
Zonguldak Karaelmas University/TR
Similares
MEDLINE
...
LILACS
LIS