Nuclear calcium signaling: a cell within a cell
Braz. j. med. biol. res
;
42(1): 17-20, Jan. 2009. ilus
Artigo
em Inglês
| LILACS
| ID: lil-505417
ABSTRACT
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Núcleo Celular
/
Receptores Proteína Tirosina Quinases
/
Sinalização do Cálcio
/
Proliferação de Células
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
/
Congresso e conferência
/
Documento de projeto
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Universidade Federal de Minas Gerais/BR
/
Universidade de Brasília/BR
/
Yale University School of Medicine/US
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