The Pneumocystis life cycle
Mem. Inst. Oswaldo Cruz
;
104(3): 419-426, May 2009. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-517005
ABSTRACT
First recognised as "schizonts" of Trypanosoma cruzi, Pneumocystis organisms are now considered as part of an early-diverging lineage of Ascomycetes. As no robust long-term culture model is available, most data on the Pneumocystis cell cycle have stemmed from ultrastructural images of infected mammalian lungs. Although most fungi developing in animals do not complete a sexual cycle in vivo, Pneumocystis species constitute one of a few exceptions. Recently, the molecular identification of several key players in the fungal mating pathway has provided further evidence for the existence of conjugation and meiosis in Pneumocystisorganisms. Dynamic follow-up of stage-to-stage transition as well as studies of stage-specific proteins and/or genes would provide a better understanding of the still hypothetical Pneumocystislife cycle. Although difficult to achieve, stage purification seems a reasonable way forward in the absence of efficient culture systems. This mini-review provides a comprehensive overview of the historical milestones leading to the current knowledge available on the Pneumocystis life cycle.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pneumocystis
/
Ciclo Celular
/
Genes Fúngicos Tipo Acasalamento
/
Estágios do Ciclo de Vida
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2009
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
França
Instituição/País de afiliação:
Pasteur Institute of Lille/FR
/
University of Lille Nord de France/FR
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