Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats
Clinics
;
64(6): 567-570, June 2009. tab
Artigo
em Inglês
| LILACS
| ID: lil-517926
ABSTRACT
BACKGROUND:
Failure of anastomotic healing is one of the major complications in colorectal surgery. Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats.METHODS:
Twenty-eight Sprague-Dawley rats were used in the study. Excision and end-to-end anastomosis was performed in the distal colon of the rat. The Famotidine Group received 2 mg/kg/day famotidine; the Control Group received the same amount of saline. Bursting pressure of anastomoses and hydroxyproline content of perianastomotic tissues were evaluated on the third and seventh days following surgery.RESULTS:
Bursting pressures and hydroxyproline contents for the Famotidine Group were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery.CONCLUSIONS:
According to our findings, famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cicatrização
/
Famotidina
/
Colo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Fatih University/TR
Similares
MEDLINE
...
LILACS
LIS