Long lasting structural changes in primary motor cortex after motor skill learning: a behavioural and stereological study
Biol. Res
;
41(4): 397-404, Dec. 2008. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-518395
ABSTRACT
Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled reaching task). Rats were trained a lateralised reaching task during an "early" (22-31 days old) or "late" (362-371 days old) postnatal period. The trained and corresponding control rats were sacrificed at day 372, immediately after the behavioural testing. The "early" trained group preserved the learned skilled reaching task when tested at day 372, without requiring any additional training. The "late" trained group showed a similar capacity to that of the "early" trained group for learning the skilled reaching task. All trained animals ("early" and "late" trained groups) showed a significant inter hemispheric decrease of neuronal density in the corresponding motor forelimb representation area of MI (cortical layers II-III).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Lateralidade Funcional
/
Aprendizagem
/
Córtex Motor
/
Destreza Motora
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2008
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
University of Chile/CL
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