La genética como factor pronóstico y terapéutico en el mieloma múltiple: [revisión] / Genetic markers as prognostic factors in multiple myeloma: [revision]
Rev. méd. Chile
;
137(4): 552-558, abr. 2009. tab
Artigo
em Espanhol
| LILACS
| ID: lil-518591
ABSTRACT
The search for prognostic factors in multiple myeloma has identified the genetic profile of the tumor as the main determinant of patient survival and response to treatment. There is an association between a dismal prognosis and the presence of t(414) translocations or 17p deletion, determined by fluorescent in situ hybridization (FISH) or the detection of chromosome 13 deletion using conventional cytogenetic techniques. These alterations define a subpopulation that comprises 25% of patients with a bad prognosis even if they are treated with high dose chemotherapy. These patients should be early derived to more specific therapies. In the other hand, the other 75% of patients without a genetic risk factor, have a higher probability of success with conventional treatment.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Mieloma Múltiplo
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Chile
/
Estados Unidos
Instituição/País de afiliação:
Mayo Clinic Comprehensive Cancer Center/US
/
Mayo Clinic Scottsdale/US
/
Universidad de Chile/CL
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