The possible role of Myosin light chain in myoblast proliferation
Biol. Res
;
42(1): 121-132, 2009. ilus
Artigo
em Inglês
| LILACS
| ID: lil-519091
ABSTRACT
Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this report, we studied the possible role of Myl in the proliferation of skeletal muscle-derived myoblasts. Compared to diaphragm-derived myoblasts, the extraocular muscle-derived myoblasts with lower levels of Myl proliferated faster, maintained a longer proliferation phase, and formed more final myotubes. It was found that blockading Myl with anti-Myl antibody or knockdown of Myll by siRNA targeted against Myll could enhance the myoblast proliferation and delay the differentiation of myoblasts. Our results suggested that Myl, likely Myll, can negatively affect myoblast proliferation by facilitating myoblast withdrawal from cell cycle and differentiation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Regeneração
/
Diafragma
/
Cadeias Leves de Miosina
/
Mioblastos
/
Proliferação de Células
/
Músculos Oculomotores
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2009
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
China
Instituição/País de afiliação:
Sichuan University/CN
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